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Apoptosis induced by cell detachment was increased in TDB-treated cells and the formation of tumor in anchorage-independent growth was found to be reduced in response to the compound.

The scientific literature reports various studies on extracts from Dendrobium plants, as well as on their isolates. focused their studies on 4,5,4’-trihydroxy-3,3’dimethoxybibenzyl (TDB) from Dendrobium ellipsophyllum and its anti-metastatic effect on lung cancer cells (H292) [ 28]. In vitro, HCT-116 human colon cancer cells were treated with DCME and its cytotoxic effect was evaluated using a MTT assay [ 23]. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Moreover, the study revealed that denbinobin inhibits the invasive phenotype of SNU-484 cells suggesting that metalloproteinase (MMP)-2 and MMP-9 may be involved in its anti-invasive activity.Dendrobium nobile alkaloids (DNLA) were studied for their effects on rat primary cultured neurons subjected to oxygen-glucose deprivation/reperfusion (OGD/RP) in vitro, in an attempt to attenuate neuronal damage in ischemic brain vascular diseases. macrophages Mouse spleen lymphocytes Bone marrow cells stimulated by the suspension of Peyer’s patch cells of female ICR mice RAW 264. Moreover, aging can be examined from an immunological point of view, because it is generally accepted, that the immune system does not work as well as we grow older and becomes altered with age.

Structure analysis indicated that DOP-W3-b was composed of mannose and glucose in a molar ratio of 4. Studies reporting anticancer effects of Dendrobium isolates focus mostly on bibenzyl and phenanthrene derivatives. Investigations focused on polysaccharides from the stems of Dendrobium nobile led to the isolation of a pectic polysaccharide DNP-W5, which was composed of mannose, glucose, galactose, xylose, rhamnose and galacturonic acid in molar ratios of 3. The majority of reported studies deal with in vitro evaluations of potential anticancer effects of crude Dendrobium extracts or isolated compounds.in different proportions were prepared and administrated to diabetic rats over a total period of 48 days. Among these bibenzyl derivatives, fimbriadimerbibenzyl A, B, E, F and G exhibited broad-spectrum and moderate cytotoxicity with IC 50 values range from 5.

This compound inhibited K562 cell viability in a concentration-dependent manner with an IC 50 value of 1. The results indicated that crepiduatol A, confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol enhanced the proportion of the NGF-induced (10 ng/mL) neurite-bearing cells at a concentration of 10 μM [ 65]. Affordable Value: Clear Breath Dendrobium Herbal Drops offer great value for money, making it accessible to everyone.In this study, it was found that DHP could activate macrophages through NF-κB, MAPKs and PI3 signaling pathways, which is evidenced by not only the changes in the phosphorylation of NF-κB, p38, ERK, JNK and Akt, but also changes in the levels of NO, TNF-α and IL-1β in cells treated with DHP alone or in combination with the specific inhibitors [ 89]. How to use -- Use a dropper to draw 1-2ml under the tongue (marked inside the dropper), 3 times a day. DNLA prevented Aβ 25-35-induced neuronal loss in the hippocampus and cortex, increased the number of Nissl bodies, improved the ultrastructural injury of neurons and increased the number of synapses in neurons. In fact, the Chinese consider Dendrobium as one of the fifty fundamental herbs used to treat all kinds of ailments and use Dendrobium tonic for longevity [ 2, 3]. compared immunomodulatory activities of polysaccharides from Dendrobium chrysotoxum (DCP), DCP-H obtained by hot water extraction (HWE) and DCP-E by enzyme-assisted extraction (EAE) [ 94].

However, only (-)- and (+)-denobilone A showed moderate inhibitory effects on HeLa, MCF-7, and A459 cells, with IC 50 values of 9. The molecular weight of the major fraction from the polysaccharides was 533 Da, and was composed of mannose, glucose and rhamnose in a molar ratio of 7. Acetylcholine and butyrylcholine esterase (AChE and BChE) activity have been used as a marker for cholinergic activity, which plays a crucial role in the learning and memory processes. com/Regulation/Dendrobium-containing-Craze-pre-workout-supplement-hit-with-CA-class-action (Accessed May 23, 2012).Bioactive tests in vitro also revealed that a rhamnoarabinogalactan DNP-W3 with Mw of 710 kDa (galactose, rhamnose and arabinose 3. Dendrobium extracts, polysaccharides and bibenzyls showed promising activities on various anti-diabetic targets ( Table 3). Chrysotobibenzyl, crepidatin, chrysotoxine, moscatilin and nobilin B, isolated from Dendrobium species, were evaluated for their protective effects against 6-hydroxydopamine (6-OHDA)-induced toxicity in the human neuroblastoma cell line SH-SY5Y. The study suggested that DOE possesses the cardioprotective potential against diabetic cardiomyopathy, which may be due to the inhibition of oxidative stress, cardiac lipid accumulation, pro-inflammatory cytokines and cardiac fibrosis. Treatment with DO significantly attenuated serum levels of TC, TG, BUN and CREA, attenuated the electroretinogram deficits and pathological changes in the eyes of diabetic rats.