Cerebrolysin : The Next Evolution of Medicine

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Alcantara-Gonzalez et al (2012) Combined Administration of Cerebrolysin and Donepezil Induces Plastic Changes in Prefrontal Cortex in Aged Mice https://www.ncbi.nlm.nih.gov/pubmed/22826038

All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: N. M. Bornstein et al., “Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials,” Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol., vol. 39, no. 4, pp. 629–640, Apr. 2018, doi: 10.1007/s10072-017-3214-0. Alvarez et al (2008) Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate–severe traumatic brain injury https://www.ncbi.nlm.nih.gov/pubmed/18273537EVER NEURO PHARMA GMBH (2020) Cerebrolysin. https://www.cerebrolysin.com/en/cerebrolysin/administration/. Accessed Sep 20, 2020 2020 W.-D. Heiss, M. Brainin, N. M. Bornstein, J. Tuomilehto, Z. Hong, and Cerebrolysin Acute Stroke Treatment in Asia (CASTA) Investigators, “Cerebrolysin in patients with acute ischemic stroke in Asia: results of a double-blind, placebo-controlled randomized trial,” Stroke, vol. 43, no. 3, pp. 630–636, Mar. 2012, doi: 10.1161/STROKEAHA.111.628537. Sharma HS, Zimmermann-Meinzingen S, Johanson CE (2010) Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat. Ann N Y Acad Sci 1199:125–137. https://doi.org/10.1111/j.1749-6632.2009.05329.x Ruther et al (2000) Sustained improvements in patients with dementia of Alzheimer’s type (DAT) 6 months after termination of Cerebrolysin therapy https://www.ncbi.nlm.nih.gov/pubmed/11005546

Ghaffarpasand F, Torabi S, Rasti A, Niakan MH, Aghabaklou S, Pakzad F, Beheshtian MS, Tabrizi R (2019) Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis. Neuropsychiatr Dis Treat 15:127–135. https://doi.org/10.2147/NDT.S186865 Alvarez et al (2006) A 24-week, double-blind, placebo-controlled study of three dosages of Cerebrolysin in patients with mild to moderate Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/16420392 Alzheimer’s disease, vascular dementia and Alzheimer-combined vascular genesis: recommended dose is 5ml-30ml.

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Yanlu Z, Michael C, Zheng Gang Z, Yi Z, Li Z, Mei L, Talan Z, Stefan W, Hemma B, Asim M, Ye X (2018) Prospective, randomized, blinded, and placebo-controlled study of Cerebrolysin dose-response effects on long-term functional outcomes in a rat model of mild traumatic brain injury. J Neurosurg 129(5):1295–1304. https://doi.org/10.3171/2017.6.JNS171007 Cerebrolysin is a combination of peptides and neurotrophins for enhancing the regeneration of neurons, neural plasticity, and neural protection during neurological illnesses, such as dementia and traumatic brain injuries. It is a neuropeptide drug formed from a series of biochemical and enzymatic reactions on porcine brain proteins. The ultimate product that is formed after a series of reactions has a low molecular weight and increased ability to cross the blood-brain barrier.