Senokot Constipation Relief Syrup - 150 ml

Product Information

If any of the side effects gets serious, or if you notice any side effect not listed in this leaflet, please speak to your doctor or pharmacist Immediately.

It will give you more information about the medicine and will provide you with a full list of the side-effects which you could experience. inhibition of absorption of water and electrolytes (Na+, Cl-) into the colonic epithelial cells (antiabsorptive effect) and increase of the leakiness of the tight junctions and stimulation of secretion of water and electrolytes into the lumen of the colon (secretagogue effect) resulting in enhanced concentrations of fluid and electrolytes in the lumen of the colon. An extract and aloe-emodin were mutagenic in in vitro tests, sennoside A, B and rhein gave negative results.If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Senokot tablets, syrup and granules contain Senna, a natural plant extract which works by stimulating the muscles in the bowel in a similar way to figs and prunes. A doctor may prescribe higher doses for adults and children up to a maximum of 4 tablets (30mg) taken once a day if necessary.

A 104-week study on rats of both genders did not reveal any carcinogenic effects with the same senna pods preparation at oral dosages of up to 300 mg/kg. Use during breastfeeding is not recommended as there are insufficient data on the excretion of metabolites in breast milk. Adults, including the elderly and children 12 years old and over: the usual dose is onetotwo5 ml spoonfuls at bedtime. In all groups epithelial hyperplasia of the large intestine of minor degree was found and was reversible within the 8-week recovery period. Adults, including the elderly and children 12 years old and over: the usual dose is one to two 5 ml spoonfuls at bedtime.When products containing senna leaf preparations are administered to incontinent adults, pads should be changed more frequently to prevent extended skin contact with faeces. Most sorts of drink will do but, as a start, try just drinking a glass of water 3-4 times a day in addition to what you normally drink. The β-Ο-linked glycosides (sennosides) are neither absorbed in the upper gut nor split by human digestive enzymes.

Storage of a brown tubular pigment led to a dark discoloration of the renal surface and still remained to a lesser degree after the recovery period.By using this site, you agree to our use of these technologies in accordance with our Privacy Policy.

If you are still constipated after taking senna for three days, make an appointment to speak with your doctor. If that does not work you can increase the dose to a maximum of 2 tablets or two 5ml spoonfuls at bedtime. chronic use may lead to albuminuria and haematuria which is albumin (protein) or red blood cells (blood) in the urine. If you are not used to a high-fibre diet, it may be best to increase the amount of fibre you eat gradually.

In contact with oxygen, rhein anthrone is oxidised into rhein and sennidins, which can be found in the blood, mainly in the form of glucuronides and sulphates. Dose-dependent tubular basophilia and epithelial hypertrophy of the kidneys were seen at a dose of, or greater than 300 mg/kg per day without functional affection. If you take it for longer, your body can start to rely on it, rather than your bowels doing the work on their own. If no bowel action has occurred after three days of progressively increased dosage, a medical examination should be considered.