Berberine Extract 1000mg 30 Capsules Vegan Organic Capsules 100% Natural by Vytox. 1 Month Supply

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Polycystic ovary syndrome (PCOS) occurs when a female has high levels of certain male hormones. The syndrome is a hormonal and metabolic imbalance that can lead to infertility and other health issues. Many factors that can be measured in your blood are associated with an increased risk of heart disease. Liang, Y., et al . (2019). Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: A systematic literature review and a meta-analysis. Berberine is an alkaloid compound that exerts antioxidant and anti-inflammatory activity, which translates to several health benefits, including:

Berberine: A Review of its Pharmacokinetics Frontiers | Berberine: A Review of its Pharmacokinetics

These extra nutrients and compounds include chromium, banaba leaf extract, vanadyl sulfate, and cinnamon, all of which have been studied for their role in reducing blood sugar or insulin resistance. Both berberine and metformin have been shown to cause changes in more than 20 genera in db/db mice (C57BLKS/JNju, animal models of type 2 diabetes). Both of these treatments caused significant changes in the expression of seven OTUs, including increases in the prevalence of a range of SCFA-producing bacteria, including Butyricimonas, Coprococcus, and Ruminococcus ( Zhang etal., 2019). Similar changes were observed in the content of SCFA-producing bacteria in the feces. Both of these treatments led to an increase in the populations of the symbiotic genera Lactobacillus and Akkermansia. In contrast, both treatments reduced the populations of Prevotella and Proteus, two types of opportunistic pathogens. Berberine and metformin were able to reduce weight gain and regulate the gut microbiome while suppressing intestinal inflammation and supporting the intestinal barrier ( Zhang etal., 2019). One review reported that people who took 750 milligrams (mg) of barberry twice a day for 3 months had a significant decrease in weight. Barberry is a plant that contains high amounts of berberine. The National Center for Complementary and Integrative Health (NCCIH) notes that if adults take goldenseal, which contains berberine, by mouth it is unlikely to cause severe adverse effects in the short term. However, there is not enough information to show that long-term use is safe.

Physical and Chemical Properties of Berberine

This well-tolerated extract works at the cellular level to support healthy blood sugar levels already in the normal range, even after eating a meal or sugary treat. This manuscript was designed by LW and XS and drafted by LZ, XW, and RY. FC, YL, ZZ, and ZW contributed to writing. All authors contributed to the article and approved the submitted version. Funding Naz, I., et al. (2022). Anti-inflammatory potential of berberine-rich extract via modulation of inflammation biomarkers [Abstract].

Berberine is a promising supplement - Mayo Clinic Press

Berberine works primarily by activating an enzyme called AMP-activated protein kinase (AMPK), which acts like a metabolic master switch that reduces blood sugar and regulates metabolism. Also, a double-blind study found that individuals with metabolic syndrome who took 200 mg of barberry three times a day experienced decreases in their body mass index readings.

Berberine is most well-known for its ability to reduce blood sugar and insulin resistance, which may reduce the risk of type 2 diabetes. Berberine can create changes within the molecules of cells, and this could have another potential benefit: fighting cancer. In particular, a number of observational studies have identified an association between elevated circulating levels of branched-chain amino acids (BCAAs) and poor metabolic health. In clinical studies, increased levels of BCAAs in the blood have been positively correlated with insulin resistance ( Lynch and Adams, 2014). Berberine has been shown to reduce the relative abundance of BCAA-producing bacteria, including Clostridiales; the families of Streptococcaceae, Clostridiaceae, the Streptococcus genera, and Prevotella. Consequently, the increased serum levels of BCAAs induced by the consumption of a high-fat diet are reduced significantly following the administration of berberine. Furthermore, data from both healthy subjects and patients with DM indicate that berberine can improve glycemic control and modulate the circulating levels of BCAAs ( Yue etal., 2019). Therefore, it is evident that the hypoglycemic effects of berberine may be related to improvements in the regulation of gut-derived hormones, the weakening of mechanisms in the intestinal mucosal, and the destruction of the immune-barrier.