Pro-Ven Probiotics Adult Digestive Supplement Vegan Acidophilus & Bifidus 25 Billion CFU Capsules Multi-Strain High Strength Friendly Bacteria 30 Capsules - UK Made

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Khalesi S, Bellissimo N, Vandelanotte C, Williams S, Stanley D, Irwin C. A review of probiotic supplementation in healthy adults: helpful or hype? Eur J Clin Nutr 2019;73:24-37. [ PubMed abstract] The potential health benefits of probiotics are the focus of a great deal of scientific research. This section focuses on research on the use of probiotics to prevent or treat seven health conditions: atopic dermatitis, pediatric acute infectious diarrhea, antibiotic-associated diarrhea (AAD), inflammatory bowel disease, irritable bowel syndrome, hypercholesterolemia, and obesity. Atopic dermatitis Caffarelli C, Cardinale F, Povesi-Dascola C, Dodi I, Mastrorilli V, Ricci G. Use of probiotics in pediatric infectious diseases. Expert Rev Anti Infect Ther 2015;13:1517-35. [ PubMed abstract] The microbiome is made up of many different species of bacteria, some of which are considered friendly and others termed pathogenic. The bacteria line the gut wall and help to stop toxins and harmful substances passing through the gut into the body – so ideally, we need a lot more good than bad. The ideal ratio has been estimated at 85% good to 15% bad bacteria and if this balance is affected it may lead to digestive symptoms such as bloating or irritable bowel syndrome (IBS). The International Scientific Association for Probiotics and Prebiotics advises manufacturers to list the total number of CFUs—ideally for each strain—on the expiration or use by date on the product label [ 74]. The association also suggests that consumers of these supplements avoid products that list the number of CFUs at time of manufacture because this information does not account for declines in CFUs over a product’s lifespan. References

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Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014;11:506-14. [ PubMed abstract] A more recent systematic review included 35 RCTs of 16 single-strain and 19 multi-strain products in 3,406 adults with IBS [ 47]. Of the studies that found a statistically significant reduction in global symptoms (14 of 29 trials) or a clinically meaningful reduction in abdominal pain (8 of 34 trials), most used multi-strain probiotic products. Furthermore, only trials of multi-strain products found a clinically meaningful improvement in quality of life [ 44, 45]. Inflammatory bowel disease (IBD) is a chronic inflammatory disease that includes ulcerative colitis and Crohn’s disease [ 30]. The exact cause of IBD is unknown but is probably a combination of inherited and environmental factors, including genetic alterations and immune system dysfunction [ 31]. Various treatments for IBD, including oral steroids and other medications, are available, but no cure exists. Assimilation and incorporation of cholesterol into bacteria [ 52], thus lowering cholesterol levels in blood

Freedman SB, Williamson-Urquhart S, Farion KJ, Gouin S, Willan AR, Poonai N, et al. Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis. N Engl J Med 2018;379:2015-26. [ PubMed abstract] ProVen Probiotics products are supported by more than 30 clinical trials and over ninety other studies and papers.

ProVen Probiotics for Women - with Cranberry and Vitamin B6 ProVen Probiotics for Women - with Cranberry and Vitamin B6

This is a fact sheet intended for health professionals. For a general overview of Probiotics, see our consumer fact sheet on Probiotics. Introduction Principi N, Cozzali R, Farinelli E, Brusaferro A, Esposito S. Gut dysbiosis and irritable bowel syndrome: The potential role of probiotics. J Infect 2018;76:111-20. [ PubMed abstract] AlFaleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev 2014:Cd005496. [ PubMed abstract]The probiotic strains used in the ProVen products are our own unique blends, known as Lab4, Lab4B and Lab4P. Meta-analyses indicate that the use of any of a few species and strains (described below) of probiotics might reduce the risk of AAD by 51% [ 27]. However, the benefits of probiotic use to prevent AAD depend on the type of antibiotic that caused the AAD, the strain(s) of probiotic used, the life stage of the user (child, younger adult, or older adult), and whether the user is receiving inpatient or outpatient care. Positive associations between intakes of probiotics and reduced risk of AAD have been found in children and adults age 18 to 64 years but not in adults age 65 years and older [ 28].

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Antibiotics are another common cause of acute-onset diarrhea. Antibiotic treatment often disturbs the intestinal microbiome and, by decreasing microbial diversity, can lead to a loss of microbial metabolism (resulting in osmotic diarrhea due to excessive fluid in the intestine), loss of colonization resistance (resulting in increased numbers of infections by other pathogens), and increased intestinal motility [ 25]. Up to 30% of patients who use antibiotics experience AAD [ 26]. Taking friendly bacteria such as Acidophilus and Bifidus alongside and following antibiotics may help to maintain a balanced microbiota. Multi-strain ultra-high-strength live bacteria Probiotics usually exert their effects in the gastrointestinal tract, where they may influence the intestinal microbiota. Probiotics can transiently colonize the human gut mucosa in highly individualized patterns, depending on the baseline microbiota, probiotic strain, and gastrointestinal tract region [ 4]. You can choose from chewable tablets and powder products, and lower amounts of friendly bacteria with higher levels of vitamins or high bacteria count with specifically selected vitamins.-

Each capsule contains 12.5 billion friendly bacteria along with key nutrients to provide additional support for digestion (calcium) and immunity (vitamins C and D, zinc and selenium). Key features

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Crovesy L, Ostrowski M, Ferreira D, Rosado EL, Soares-Mota M. Effect of Lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials. Int J Obes (Lond) 2017;41:1607-14. [ PubMed abstract] Kaur L, Gordon M, Baines PA, Iheozor-Ejiofor Z, Sinopoulou V Akobeng AK. Probiotics for induction of remission in ulcerative colitis. Cochrane Database Syst Rev 2020; 3: Cd005573. [ PubMed abstract]Sanders ME. Clinical use of probiotics: what physicians need to know. Am Fam Physician 2008;78:1026. [ PubMed abstract]