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The essential trace element zinc plays a key role for several important biological processes in the human body [ 1]. To compensate the endogenous zinc loss and maintain a healthy zinc homeostasis, this micronutrient has to be supplied with food on a daily basis [ 2]. Human body zinc homeostasis is predominantly regulated by its intestinal absorption [ 3]. In this process, zinc transporters on the apical and basolateral membrane of enterocytes are engaged and regulate cellular and body zinc homeostasis together with the cellular zinc-binding protein metallothionein [ 4, 5]. Despite this knowledge and ongoing research, a deeper understanding of the molecular processes regulating zinc absorption via the intestinal epithelium is still scarce. Zinc absorption does not only depend on an adequate dietary intake, but is also greatly affected by its intestinal availability from the diet. To further illuminate the impact of these factors on zinc absorption by the intestinal epithelium remains one of the determining topics in research [ 6, 7]. Herein, in vivo human studies using (stable) isotope techniques are still the gold standard [ 8]. During the past 50 years, attempts to establish suitable three-dimensional in vitro cell culture models to mimic in vivo processes have gained more attention. This is mainly due to high costs and ethical standards of animal studies and the benefits of in vitro models providing a microenvironment that advances studies of cellular processes on a molecular level [ 9, 10]. Garden of Life is a whole foods-based supplement brand with products that are certified organic and non-GMO verified.
Zinc contributes to normal protein synthesis including keratin and collagen synthesis. One of the important zinc dependent proteins is Gustin, which is involved in taste and smell. Poor or absent gustin levels results in impaired taste and smell, as shown in this zinc research on protein synthesis. Zinc has essential structural, regulatory or catalytic roles in many enzymes. Many of the enzymes of the intermediate metabolism contain zinc and the deficiency of zinc affects the metabolism of all macronutrients. Protein synthesis, DNA synthesis and RNA synthesis all require zinc and lipid metabolism is also affected, with zinc deficiency being associated with reductions in circulating high-density lipoprotein. remove Most people in the United States get enough zinc from their food, the NIH reports. But people with limited food intake and people in the following groups may find it difficult:
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Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM, Kerkeni A. Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. J Am Coll Nutr. 2001;20(3):212-218.
Ensuring you have enough zinc can increase the quality and quantity of your sleep. Low zinc levels can lead to insomnia, and supplementing zinc is often recommended as a treatment for insomnia. 7. Age-Related Muscle Deterioration
There is a strong correlation between male fertility and levels of zinc in the body. It is an essential nutrient for male fertility and plays a role in determining the quality of sperm and the sperm's ability to fertilize an egg. National Academy of Sciences. Dietary Reference Intakes (DRIs): Recommended Intakes for Individuals, Vitamins. Accessed June 1, 2011. It is best to wait for a final diagnosis of deficiency before taking supplements, as the symptoms commonly associated with low magnesium levels could be the cause of another health issue. Shay NF, Manigan HF. Neurobiology of zinc-influenced eating behavior. J Nutr. 2000;130:1493S-1499S.
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