Yves Saint Laurent Opium Neon Black Eau De Parfum Spray For Women 75 ml

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Opium was for many centuries the principal painkiller known to medicine and was used in various forms and under various names. Laudanum, for example, was an alcoholic tincture (dilute solution) of opium that was used in European medical practice as an analgesic and sedative. Physicians relied on paregoric, a camphorated solution of opium, to treat diarrhea by relaxing the gastrointestinal tract. The narcotic effects of opium are mainly attributable to morphine, which was first isolated about 1804. In 1898 it was discovered that treating morphine with acetic anhydride yields heroin, which is four to eight times as potent as morphine in both its pain-killing properties and its addictive potential. The other alkaloids naturally present in opium are much weaker; codeine, for example, is only one-sixth as potent as morphine and is used mainly for cough relief. Since the late 1930s, various synthetic drugs have been developed that possess the analgesic properties of morphine and heroin. These drugs, which include meperidine (Demerol), methadone, levorphonal, and many others, are known as synthetic opioids. They have largely replaced morphine and heroin in the treatment of severe pain. Morewood, Samuel (1838). A philosophical and statistical history of the inventions and customs of ancient and modern nations in the manufacture and use of inebriating liquors; with the present practice of distillation in all its varieties: together with an extensive illustration of the consumption and effects of opium, and other stimulants used in the East, as substitutes for wine and spirits. Dublin, W. Curry and W. Carson. Peters, Gretchen. Seeds of Terror: How Heroin is Bankrolling the Taliban and Al Qaeda, Thomas Dunne Books (2009). The production methods have not significantly changed since ancient times. Through selective breeding of the Papaver somniferum plant, the content of the phenanthrene alkaloids morphine, codeine, and to a lesser extent thebaine has been greatly increased. In modern times, much of the thebaine, which often serves as the raw material for the synthesis for oxycodone, hydrocodone, hydromorphone, and other semisynthetic opiates, originates from extracting Papaver orientale or Papaver bracteatum.

Between 400 and 1200 CE, Arab traders introduced opium to China, and to India by 700. [19] [1] [12] [20] The physician Muhammad ibn Zakariya al-Razi of Persian origin ("Rhazes", 845–930 CE) maintained a laboratory and school in Baghdad, and was a student and critic of Galen; he made use of opium in anesthesia and recommended its use for the treatment of melancholy in Fi ma-la-yahdara al-tabib, "In the Absence of a Physician", a home medical manual directed toward ordinary citizens for self-treatment if a doctor was not available. [21] [22] The renowned Andalusian ophthalmologic surgeon Abu al-Qasim al-Zahrawi ("Abulcasis", 936–1013 CE) relied on opium and mandrake as surgical anesthetics and wrote a treatise, al-Tasrif, that influenced medical thought well into the 16th century. [23] Smith RD (October 1980). "Avicenna and the Canon of Medicine: a millennial tribute". The Western Journal of Medicine. 133 (4): 367–70. PMC 1272342. PMID 7051568. Liang, Bin; Lu, Hong (2013). "Discourses of drug problems and drug control in China: Reports in the People's Daily, 1946–2009". China Information. 27 (3): 302. doi: 10.1177/0920203X13491387. S2CID 147627658. Heroin (diacetylmorphine) is derived from the morphine alkaloid found in opium and is roughly 2 to 3 times more potent. A highly addictive drug, heroin exhibits euphoric ("rush"), anxiolytic and analgesic central nervous system properties.Despite drastic penalties and continued prohibition of opium until 1860, opium smuggling rose steadily from 200 chests per year under the Yongzheng Emperor to 1,000 under the Qianlong Emperor, 4,000 under the Jiaqing Emperor, and 30,000 under the Daoguang Emperor. [61] The illegal sale of opium became one of the world's most valuable single commodity trades and has been called "the most long continued and systematic international crime of modern times". [62] Opium smuggling provided 15 to 20 percent of the British Empire's revenue and simultaneously caused scarcity of silver in China. [63]

Robinson SL, Rowbotham DJ, Smith G (July 1991). "Morphine compared with diamorphine. A comparison of dose requirements and side-effects after hip surgery". Anaesthesia. 46 (7): 538–40. doi: 10.1111/j.1365-2044.1991.tb09650.x. PMID 1862890. S2CID 35289009. Opium Factories of Bihar – Bihargatha". Bihargatha.in. Archived from the original on September 10, 2011 . Retrieved October 7, 2011. Opium timeline". The Golden Triangle. Archived from the original on April 20, 2009 . Retrieved September 13, 2009.

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Smoking, snorting or orally ingesting heroin does not produce an intense "rush" as might be experienced with intravenous (IV) injection. Albert D. Fraser & David Worth (October 1999). "Experience with a Urine Opiate Screening and Confirmation Cutoff of 2000 mg/ml". Journal of Analytical Toxicology. 23 (6): 549–551. doi: 10.1093/jat/23.6.549. PMID 10517566. Hall, Wayne; Weier, Megan (2017). "Lee Robins' studies of heroin use among US Vietnam veterans". Addiction. 112 (1): 177. doi: 10.1111/add.13584. PMID 27650054. S2CID 206974500 . Retrieved July 26, 2022. Anderson, Stuart; Berridge, Virginia (2000). "Opium In 20th-Century Britain: Pharmacists, Regulation And The People". Addiction. 95 (1): 23–36. doi: 10.1046/j.1360-0443.2000.951234.x. PMID 10723823. PAPADAKI, P. G. KRITIKOS, S. P. "The history of the poppy and of opium and their expansion in antiquity in the eastern Mediterranean area". Unodc.org. UNODC- Bulletin on Narcotics – 1967 Issue 4 – 002 . Retrieved May 31, 2022. {{ cite web}}: CS1 maint: multiple names: authors list ( link)

Some opium has been found to be contaminated with lead. The source of lead in opium is still unclear, possibly due to contamination from equipment used to process the opium, intentional adulteration of opium with lead to increase its weight, or from growing opium poppies in contaminated soil. 9, 10 a b c Yangwen Zheng (2003). "The Social Life of Opium in China, 1483–1999". Modern Asian Studies. 37 (1): 1–39. doi: 10.1017/S0026749X0300101X. S2CID 146582691.Ballantyne, Jane C., and Jianren Mao. "Opioid Therapy For Chronic Pain". New England Journal of Medicine 349.20 (n.d.): 1943–1953. SocINDEX with Full Text. Web. November 3, 2011. Oral ingestion does not usually lead to a "rush", but use of heroin in suppository form may have intense euphoric effects. Armero and Rapaport. The Arts of an Addiction. Qing Dynasty Opium Pipes and Accessories (privately printed, 2005) The use of diethyl ether and chloroform for general anesthesia began in 1846–1847, and rapidly displaced the use of opiates and tropane alkaloids from Solanaceae due to their relative safety. [103] Peter Dale Scott, Asia-Pacific Journal Japan Focus, 1 Nov. 2010, Volume 8 | Issue 44 | Number 2, "Operation Paper: The United States and Drugs in Thailand and Burma" 米国とタイ・ビルマの麻薬