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Dentistry is known to be stressful [1] but would it surprise you to learn that 85% of us live every day with the consequences of high-pressure lives and struggle to cope with stress and anxiety? Many of us suffer stress-related symptoms ranging from sleeplessness to tooth grinding – which we may feel are not severe enough for medication, yet negatively impact our lives [2]. The Serenitas-1714 culture in Zenflore is totally natural and is part of the family of bacteria given by mother to baby at birth and naturally at home in the human gut, plus it doesn’t make me drowsy the next day, so I will be staying on it.’ B. longum 1714™ altered resting-state neural oscillations, with an increase in theta band power in the frontal and cingulate cortex ( P< 0.05) and a decrease in beta-3 band in the hippocampus, fusiform, and temporal cortex ( P< 0.05), both of which were associated with subjective vitality changes. All groups showed increased social stress after a 4-week intervention without an effect at behavioral level due to small sample numbers. However, only B. longum 1714™ altered neural oscillation after social stress, with increased theta and alpha band power in the frontal and cingulate cortex ( P< 0.05) and supramarginal gyrus ( P< 0.05). DISCUSSION: Zenflore are capsules designed to give support for your mind and body during busy and demanding times. Regarding the gut brain axis, the strain bifidobacterium longum 1714 also called 1714 Serenitas– was developed and researched in partnership with the University of Cork’s APC Institute – a world leader in microbiome research – specifically for its effects on stress and the brain (see the research below).
From an evolutionary perspective, humans are programmed to be highly sensitive to social exclusion and have developed monitoring systems to detect cues ( 30,31). This is necessary for human survival as social isolation is often a fatal threat ( 32,33). As expected, the CBG induced a social stress effect at baseline across all participants. Social exclusion produced differential neural oscillations in all frequency bands in various areas, such as frontal, temporal, and fusiform cortex. These results were similar to previous EEG and MEG studies, showing modulation of neural oscillations by social exclusion ( 14,15,17,21). Previously reported ACC activations were related to processing of negative emotions and event appraisal due to the social stress/exclusion, and PFC activation was related to emotional regulation ( 13,34–36). Theta band oscillations in ACC and insula were described as a marker of social pain in the context of the CBG and was also found during a cold pressor test and physical pain ( 37,38). The participants reported enlarged subjective distress and decreased mood level during the exclusion condition compared with the inclusion condition, consistent to previous studies ( 12,14,15,17). After the intervention, as expected, all participants reported higher distress level during the exclusion condition compared with the inclusion condition after 4 weeks, regardless of the type of intervention (probiotic, placebo). However, a clinical effect of B. longum 1714™ on reducing stress was not observed—the study was not powered to detect differences in subjective stress. Furthermore, as with other stress paradigms, the repetition of stress may reinforce the feeling of being excluded and consolidated the memory of the stressful event making it difficult to detect differences with small numbers. Accumulating evidence indicates that the gut microbiota communicates with the CNS, possibly through neural, endocrine, and immune pathways, and influences brain function.
Did you know there’s a connection between our brain and our gut? I’ve always wondered how the phrase ‘gut feeling’ worked and now I understand it. Thanks to the explanation of the gut-brain axis, which is the two-way dialogue between our brains and our gut. If you’ve ever said you have a ‘gut feeling’ or ‘have butterflies’ to explain how you’re feeling then this is all linked to the gut-brain axis. I know I have. Financial support: The research leading to these results has received funding from the People Programme of the European Union's Seventh Framework Programme under REA grant agreement no. 607652 (NeuroGut). Neural activities in different frequency bands during exclusion vs inclusion condition. ( a) Theta frequency band (6 Hz): increased power in the bilateral cerebellum (CBL), right middle and inferior frontal cortex (MFC and IFC), left fusiform cortex ( P = 0.004); decreased power in the left middle frontal and bilateral superior frontal cortex (SFC) ( P = 0.02). ( b) Alpha frequency band (11 Hz): increased power in the bilateral CBL, left fusiform, right inferior occipital cortex ( P = 0.002); decreased power in the right SFC ( P< 0.05). ( c) Beta-1 frequency band (16 Hz): increased power in the bilateral CBL, left MFC, left inferior temporal, right middle and superior temporal cortex, and right parahippocampal ( P = 0.004). ( d) Beta-2 frequency band (21 Hz): increased power in the right CBL, left IFC, right inferior and middle temporal cortex (MTC) ( P = 0.002). ( e) Beta-3 frequency band (26 Hz): increased power in the bilateral CBL, right fusiform, left parahippocampal, left MTC ( P = 0.04). B. longum 1714™ altered resting-state brain activity measured by MEG ZenfloreⓇ is suitable for those dealing with the challenges and demands of everyday life. ZenfloreⓇ is not a medicine and is not a substitute for any medication prescribed for you by your doctor. Do not discontinue any medication without consulting your doctor. The strain bifidobacterium longum 1714 has been developed and researched at the University of Cork specifically for its effects on the brain. Called a ‘psychobiotic’, it was launched this month as an over-the-counter probiotic, Zenflore which comes from the same stable as Alflorex, and which has been shown in published, peer-reviewed studies to help alleviate mild anxiety and stress.
The existence of bidirectional communication between the gut and brain has long been established. Recently, a body of work has suggested that the commensal gut microbiota plays an important role in modulating the gut-brain axis, possibly through immune, endocrine, and neural system pathways ( 1). This has led to increased interest in modulating the gut microbiota to target central nervous system (CNS) functions and improve human behavior especially in areas such as stress, mood, anxiety, and cognition. Probiotics may represent a safe and effective way of targeting CNS function. Indeed, an abundance of preclinical studies have shown that probiotics acting through the gut-brain axis can affect brain development, function, and behavior ( 2). However, the translation of promising preclinical signals into human subjects with certain probiotic strains has proven challenging ( 3). Therefore, there is a need for more detailed mechanistic insights into the interaction between the gut microbiota and brain function in humans.
That was certainly the case for Louise Riis, whose worst bout of insomnia was when she was working as a magazine editor and dealing with a severe illness in the family.
One theory is that the vagus nerve – a long, critical nerve extending from the abdomen to the brain – acts as a neural highway for chemicals made in the gut to get to the brain. In other words, chemicals secreted by microbes in the gut could switch genes on and off in the gut lining, affecting the brain. Sleeping pills worked, but they made me drowsy the day after and I certainly wouldn’t take them while I was pregnant or as a new mum as Clara often needs me during the night,’ says Louise, who runs the successful lifestyle blog louiseloveslondon.com. ZenfloreⓇ contains the unique and highly beneficial strain of bacteria 1714-SerenitasⓇ which goes to work directly where it is needed in the gut. This strain is a member of the Bifidobacterium family and is one of the ‘good’ bacteria inhabiting the gut. It is also contained in breastmilk and is passed to babies at birth to assist in healthy immune system development, thus making it a particularly special strain. It acts in the gut to stimulate the production of mood-boosting serotonin and has shown to increase activity in the areas of the brain associated with emotions, learning, and memory. The specially selected B vitamins contribute to the reduction of stress and fatigue and encourage normal psychological function. And indeed, the Zenflore probiotic Louise took containing the Serenitas 1714 culture (see above) – though not studied yet specifically on sleep – has been shown to have a direct effect on stress levels.A unique probiotic strain that, when paired with specially selected B vitamins, fights fatigue and supports mental performance. We’ve long known of a connection between the stomach and the brain. ‘Butterflies’ in the stomach and ‘gut-wrenching’ feelings are clear examples of this phenomenon. Information is sent instantly from the gut to the brain via the nervous and immune systems, and through hormones (the endocrine system).
Although both placebo and probiotic groups reported higher subjective distress, changes in neural processing of social stress were observed only after B. longum 1714™ consumption and not placebo. In addition, the correlation between changes in subjective distress and neural activities was seen only with B. longum 1714™. Therefore, these data support the notion that B. longum 1714™ may play a role in managing stress responses by modulating the relevant neural processes; B. longum 1714™ affecting individuals' neurophysiology is a novel finding and was previously only reported for behavioral data in animals and humans ( 4–6). Exciting new research suggests the key to better sleep might be in your gut bacteria. Editor Anna Magee reports on the rise of the new sleepbiotics B. longum 1714™ has been shown to reduce stress-related behaviors in preclinical studies and improve stress responses and cognitive function in healthy volunteers.Summarized correlations of changes of averaged power in activated areas with changes of subjective results DISCUSSION In the current trial, we hypothesized that the probiotic strain B. longum 1714™ alters resting-state brain activity and neurophysiological responses to CBG-induced social stress. We assumed that during the CBG, stress-related neural oscillations of the theta and alpha band power would be changed after probiotic treatment. The results confirmed that B. longum 1714™ modulated neural responses during social stress, suggesting counter-regulation of negative emotions. METHODS Participants Another study by Swedish and German researchers took a group of normal, healthy men with normal sleep patterns and found that when their sleep was disrupted by jet lag, so too fascinatingly, was their gut composition with in an increase in types of bacteria known to increase risk of obesity and type 2 diabetes. Prebiotics and sleep I worry a lot and the moment I put my head on the pillow I start thinking about things I need to do the following day.’ Louise’s problem with sleep has got worse since becoming a mum to Clara, who is now nine months old. London blogger Louise Riis, 42, struggled to remember a time when she could sleep well and her insomnia got worse when she became a mum ZENFLORE® supports both your mind and body through life’s daily challenges. Scientifically formulated with the unique Bifidobacterium longum 1714-Serenitas culture plus 8 vitamins and minerals including vitamin B6, vitamin B12, biotin, niacin and thiamine
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