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Evaluate efficacy of compression with surgical gloves to prevent nanoparticle albumin-bound paclitaxel-associated peripheral neuropathy Evaluation before the start of each cycle and 3 weeks after the last chemotherapy in the regional cooling group. Retrospective data from historical cohort provided data from comparable time points Similar benefit after subsequent chemo cycles (odds ratio: 0.59; 95% CI = 0.46–0.76, p< .0001), although analysis of impact of preexisting peripheral neuropathy not performed in statistics for late peripheral neuropathy group

The Impact of Peripheral Cooling on Chemotherapy-Induced

Frozen Birthday Shirt , Elsa Birthday Shirts, Frozen Custom Shirt , Frozen Personalized Tee, Frozen Family Party shirts Mols F., Beijers T., Vreugdenhil G., & van de Poll-Franse L. (2014). Chemotherapy-induced peripheral neuropathy and its association with quality of life: A systematic review. Supportive Care in Cancer, 22( 8), 2261–2269. 10.1007/s00520-014-2255-7 [ PubMed] [ CrossRef] [ Google Scholar] de Lemos M. L., & Walisser S. (2005). Management of extravasation of oxaliplatin. Journal of Oncology Pharmacy Practice, 11( 4), 159–162. 10.1191/1078155205jp165oa [ PubMed] [ CrossRef] [ Google Scholar] Pérez Fidalgo J. A., García Fabregat L., Cervantes A., Margulies A., Vidall C., & Roila F. (2012). Management of chemotherapy extravasation: ESMO-EONS Clinical Practice Guidelines. Annals of Oncology, 23( Suppl 7), vii167–vii173. 10.1093/annonc/mds294 [ PubMed] [ CrossRef] [ Google Scholar] Frozen Elsa Ice Queen Girls Birthday Shirt, Frozen Birthday Shirt, Elsa Birthday shirt, Frozen Inspired Shirt, Frozen Applique ShirtSeretny M., Currie G. L., Sena E. S., Ramnarine S., Grant R., MacLeod M. R.,...Fallon M. (2014). Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain, 155( 12), 2461–2470. 10.1016/j.pain.2014.09.020 [ PubMed] [ CrossRef] [ Google Scholar] Pereira S., Fontes F., Sonin T., Dias T., Fragoso M., Castro-Lopes J. M., & Lunet N. (2016). Chemotherapy-induced peripheral neuropathy after neoadjuvant or adjuvant treatment of breast cancer: A prospective cohort study. Supportive Care in Cancer, 24( 4), 1571–1581. 10.1007/s00520-015-2935-y [ PubMed] [ CrossRef] [ Google Scholar]

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Hershman D. L., Lacchetti C., & Loprinzi C. L. (2014). Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline Summary. Journal of Oncology Practice, 10( 6), e421–e424. 10.1200/JOP.2014.001776 [ PubMed] [ CrossRef] [ Google Scholar] Komen M. M., Smorenburg C. H., van den Hurk C. J., & Nortier J. W. (2013). Factors influencing the effectiveness of scalp cooling in the prevention of chemotherapy-induced alopecia. Oncologist, 18( 7), 885–891. https://dx.doi.org/10.1634%2Ftheoncologist.2012-0332 [ PMC free article] [ PubMed] [ Google Scholar] Determine whether limb hypothermia is protective against paclitaxel-induced peripheral neuropathy and assess safety and tolerability

One of the two studies that applied a relatively lesser amount of cooling as defined in this review achieved statistically significant benefits in the severity of peripheral neuropathy ( Tsuyuki et al., 2016). This prospective, self-controlled study included 42 breast cancer patients who received compression therapy with two surgical gloves sized one size too small worn on the dominant hand, which resulted in a decrease in fingertip temperature on the intervention side. Subjects received nab-paclitaxel every 3 weeks for four cycles. Outcomes were measured using the CTCAE and the PNQ and were recorded at baseline, before each treatment cycle, and 1 week after nab-paclitaxel was administered. CTCAE results demonstrated a decrease in the incidence of ≥ grade 2 peripheral neuropathy on the intervention side ( p< .0001). The occurrence of ≥ grade 2 sensory neurotoxicity decreased from 76.1% to 21.4%, and that of motor neurotoxicity decreased from 57.1% to 26.2%. Patient Neuropathy Questionnaire results demonstrated significantly lower grades of peripheral neuropathy on the intervention side ( p< .0001). The single study in this review that achieved fingertip cooling by compression with surgical gloves demonstrated statistically significant benefits with the intervention ( Tsuyuki et al., 2016). It should be noted that it is uncertain to what degree the observed benefit in this study is attributed to a decrease in circulation at target tissues compared with a resulting decrease in temperature. Additional studies are needed to further assess the validity of the findings in the Tsuyuki study and to discern benefit from compression compared with direct cooling. Fingertip cooling by compression offers a promising area for further study given its low cost, ease of application, and seemingly good tolerability. Olaf Shirt, Disney Olaf Shirt, Disneyland Shirt, Disney Trip Shirt, Disneyworld Shirt, Elsa And Olaf Shirt, Olaf Summer Shirt

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Decreased impairment on intervention side: hand tactile sensitivity (27.8% vs. 80.6%, p< .001), foot tactile sensitivity (25.0% vs 63.9%, p< .001), hand warm sense (8.8% vs. 32.4%, p = .02), foot warm sense (33.4% vs. 57.6%, p = .04), and manipulative dexterity ( p = .005) Personalised Frozen Night Light | Elsa | Children's Light | Girls Night Light | LED Light | Birthday gift | Christmas gift | Girls gift Hanai A., Ishiguro H., Sozu T., Tsuda M., Yano I., Nakagawa T.,...Tsuboyama T. (2018). Effects of cryotherapy on objective and subjective symptoms of paclitaxel-induced neuropathy: Prospective self-controlled trial. Journal of the National Cancer Institute, 110( 2), 141–148. 10.1093/jnci/djx178 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]

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Improved preservation of sensory nerve action potential amplitude in the sural nerve. Did not achieve statistical significance ( p = .16)Tsuyuki S., Senda N., Kanng Y., Yamaguchi A., Yoshibayashi H., Kikawa Y.,...Inamoto T. (2016). Evaluation of the effect of compression therapy using surgical gloves on nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: A phase II multicenter study by the Kamigata Breast Cancer Study Group. Breast Cancer Research in Treatment, 160( 1), 61–67. 10.1007/s10549-016-3977-7 [ PubMed] [ CrossRef] [ Google Scholar] Scotte F., Tourani J. M., Banu E., Peyromaure M., Levy E., Marsan S.,...Oudard S. (2005). Multicenter study of a frozen glove to prevent docetaxel-induced onycholysis and cutaneous toxicity of the hand. Journal of Clinical Oncology, 23( 19), 4424–4429. 10.1200/JCO.2005.15.651 [ PubMed] [ CrossRef] [ Google Scholar] Keep collections to yourself or inspire other shoppers! Keep in mind that anyone can view public collections - they may also appear in recommendations and other places. Although clinical exams for neuropathy and total neuropathy scores were performed, comparisons between intervention and control side not included in evaluation