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Matarrelli B, Vitacolonna E, D'Angelo M, et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. J Matern Fetal Neonatal Med 2013;26(10):967-72. View abstract. Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes. Cochrane Database Syst Rev. (2023-Feb-15) Kamenov Z, Kolarov G, Gateva A, Carlomagno G, Genazzani AD. Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol 2015;31(2):131-5. View abstract.
Inositol and Choline? | livestrong What Are the Benefits of Inositol and Choline? | livestrong
The addition of folic acid to inositol supplements should be viewed with particular caution. Several recent studies have associated PCOS with MTHFR gene mutations [ 54, 55]. For these women, taking folic acid during pregnancy can affect childhood lung function [ 56]. Supplementing with methyl folate, the active form of folate is generally advised for PCOS patients instead of folic acid [ 57]. Levine J, Barak Y, Gonzalves M, Szor H, Elizur A, Kofman O, Blemaker RH. Double-blind, controlled trial of inositol treatment of depression. Am J Psychiatry. 1995;152(5):792-794. doi:10.1176/ajp.152.5.792 PCOS causes the ovaries or adrenal glands to produce excessive levels of male sex hormones, which can affect fertility and insulin resistance. Santamaria, A., et al. (2018). Clinical and metabolic outcomes in pregnant women at risk for gestational diabetes mellitus supplemented with myo-inositol: A secondary analysis from 3 RCTs [Abstract]. Glycemic Control - Iuorno MJ, Jakubowicz DJ, Baillargeon JP, Dillon P, Gunn RD, Allan G, Nestler JE Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome Endocr Pract. (2002 Nov-Dec)Mashayekh-Amiri S, Delavar MA, Bakouei F, Faramarzi M, Esmaeilzadeh S. The impact of myo-inositol supplementation on sleep quality in pregnant women: a randomized, double-blind, placebo-controlled study. J Matern Fetal Neonatal Med. 2020:1-9. View abstract. Phelps DL, Ward RM, Williams RL, et al. Pharmacokinetics and safety of a single intravenous dose of myo-inositol in preterm infants of 23-29 wk. Pediatr Res 2013;74(6):721-9. View abstract. Giordano D, Corrado F, Santamaria A, et al. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: A perspective, randomized, placebo-controlled study. Menopause. 2011;18(1):102-104. doi:10.1097/gme.0b013e3181e8e1b1
Inositol: Uses, benefits, and risks - Medical News Today
W.A., et al., Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care, 2000. 23(9): p. 1227-31. A.D., et al., Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients. Gynecol Endocrinol, 2014. 30(6): p. 438-43. et al., Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial. Gynecol Endocrinol, 2017. 33(7): p. 524-528. Problems with insulin sensitivity may be one of the causes of reduced fertility in women with PCOS. Since inositol may improve insulin sensitivity, it has been studied as a potential treatment ( 14).One of the ways it does this is to increase “alpha brain waves”– a type of brain wave that is associated with calm and relaxation 4 L-theanine, a natural constituent in tea, and its effect on mental state– Owen et al. | 2008 |Asia Pacific Journal of Clinical Nutrition. Fertility - Unfer V, Carlomagno G, Rizzo P, Raffone E, Roseff S Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial Eur Rev Med Pharmacol Sci. (2011 Apr) D. and R. Tal, Inositol Treatment and ART Outcomes in Women with PCOS. Int J Endocrinol, 2016. 2016: p. 1979654. Psoriasis Symptoms - Allan SJ, Kavanagh GM, Herd RM, Savin JA The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial Br J Dermatol. (2004 May)